Abstract |
Patients with anti-thyroid antibodies (ATAs) present various kinds of psychiatric conditions. When these psychiatric patients with ATAs (PPATs) show responsiveness to immunotherapy, they are frequently diagnosed with a diffuse progressive type of Hashimoto's encephalopathy (HE). Anti- glutamate receptor ɛ2 subunit (GluRɛ2) antibodies have previously been reported in HE patients. However, it is unclear whether there is any relationship between PPATs, including HE patients, and anti-GluRɛ2 antibodies. We investigated anti-GluRɛ2 antibodies in the serum and cerebrospinal fluid (CSF) of 15 PPATs, and we compared the results with those of 11 patients with neuropsychiatric systemic lupus erythematosus (NPSLE), an anti- glutamate receptor antibody-related disease. We then compared the neuropsychiatric symptoms between the PPATs with and without anti-GluRɛ2 antibodies. The prevalence of anti-GluRɛ2 antibodies was significantly higher in the CSF than in the serum of PPATs (41.7% versus 6.7%; p=0.040). The prevalence of anti-GluRɛ2 antibodies was slightly higher in the CSF of PPATs than NPSLE patients. PPAT-GluR(+)s showed a significantly higher prevalence of emotional instability (100% versus 33.3%; p=0.03) and also showed a significantly lower prevalence of delusions (0% versus 100%; p=0.001) and hallucinations (17% versus 83%; p=0.038) than PPAT-GluR(-)s. Our results suggest that anti-GluRɛ2 antibodies may be associated with the neuropsychiatric manifestation of PPATs.
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Authors | Yuhei Chiba, Omi Katsuse, Yukitoshi Takahashi, Makoto Yoneda, Misako Kunii, Atsushi Ihata, Atsuhisa Ueda, Mitsuhiro Takeno, Takashi Togo, Yoshio Hirayasu |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 534
Pg. 217-22
(Feb 08 2013)
ISSN: 1872-7972 [Electronic] Ireland |
PMID | 23142717
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Autoantibodies
- NR2B NMDA receptor
- Receptors, N-Methyl-D-Aspartate
- Thyroglobulin
- Iodide Peroxidase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Autoantibodies
(blood, cerebrospinal fluid)
- Case-Control Studies
- Female
- Humans
- Iodide Peroxidase
(immunology)
- Lupus Erythematosus, Systemic
(complications, immunology)
- Male
- Mental Disorders
(complications, immunology)
- Middle Aged
- Receptors, N-Methyl-D-Aspartate
(immunology)
- Thyroglobulin
(immunology)
- Thyroid Diseases
(complications, immunology)
- Thyroid Gland
(immunology)
- Young Adult
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