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Anti-glutamate receptor ɛ2 antibodies in psychiatric patients with anti-thyroid autoantibodies--a prevalence study in Japan.

Abstract
Patients with anti-thyroid antibodies (ATAs) present various kinds of psychiatric conditions. When these psychiatric patients with ATAs (PPATs) show responsiveness to immunotherapy, they are frequently diagnosed with a diffuse progressive type of Hashimoto's encephalopathy (HE). Anti-glutamate receptor ɛ2 subunit (GluRɛ2) antibodies have previously been reported in HE patients. However, it is unclear whether there is any relationship between PPATs, including HE patients, and anti-GluRɛ2 antibodies. We investigated anti-GluRɛ2 antibodies in the serum and cerebrospinal fluid (CSF) of 15 PPATs, and we compared the results with those of 11 patients with neuropsychiatric systemic lupus erythematosus (NPSLE), an anti-glutamate receptor antibody-related disease. We then compared the neuropsychiatric symptoms between the PPATs with and without anti-GluRɛ2 antibodies. The prevalence of anti-GluRɛ2 antibodies was significantly higher in the CSF than in the serum of PPATs (41.7% versus 6.7%; p=0.040). The prevalence of anti-GluRɛ2 antibodies was slightly higher in the CSF of PPATs than NPSLE patients. PPAT-GluR(+)s showed a significantly higher prevalence of emotional instability (100% versus 33.3%; p=0.03) and also showed a significantly lower prevalence of delusions (0% versus 100%; p=0.001) and hallucinations (17% versus 83%; p=0.038) than PPAT-GluR(-)s. Our results suggest that anti-GluRɛ2 antibodies may be associated with the neuropsychiatric manifestation of PPATs.
AuthorsYuhei Chiba, Omi Katsuse, Yukitoshi Takahashi, Makoto Yoneda, Misako Kunii, Atsushi Ihata, Atsuhisa Ueda, Mitsuhiro Takeno, Takashi Togo, Yoshio Hirayasu
JournalNeuroscience letters (Neurosci Lett) Vol. 534 Pg. 217-22 (Feb 08 2013) ISSN: 1872-7972 [Electronic] Ireland
PMID23142717 (Publication Type: Journal Article)
CopyrightCopyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Autoantibodies
  • NR2B NMDA receptor
  • Receptors, N-Methyl-D-Aspartate
  • Thyroglobulin
  • Iodide Peroxidase
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Autoantibodies (blood, cerebrospinal fluid)
  • Case-Control Studies
  • Female
  • Humans
  • Iodide Peroxidase (immunology)
  • Lupus Erythematosus, Systemic (complications, immunology)
  • Male
  • Mental Disorders (complications, immunology)
  • Middle Aged
  • Receptors, N-Methyl-D-Aspartate (immunology)
  • Thyroglobulin (immunology)
  • Thyroid Diseases (complications, immunology)
  • Thyroid Gland (immunology)
  • Young Adult

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