Epicardial and endocardial localized 31P magnetic resonance spectroscopy: evidence for metabolic heterogeneity during regional ischemia.

Previous studies have noted that myocardial blood flow and high energy phosphates are heterogeneous across the myocardial wall during ischemia. In order to determine whether differences in metabolites between the subendocardium and subepicardium could be detected using 31P magnetic resonance spectroscopy, the Fourier series window (FSW) experiment was implemented on a porcine model of graded regional ischemia. FSW experiments using a planar phantom showed a 46% improvement in localization to the subendocardium compared to a one-pulse experiment. Animal studies of graded ischemia demonstrated a gradient in the phosphocreatine to inorganic phosphate ratio in the myocardium that paralleled the gradient in blood flow. These studies demonstrate the ability of spatially localized 31P magnetic resonance spectroscopy to detect regional changes in myocardial high energy phosphates localized to the subepicardium and subendocardium.
AuthorsJ R Gober, S Schaefer, S A Camacho, M DeGroot, R Obregon, E H Botvinick, M Weiner, B Massie
JournalMagnetic resonance in medicine (Magn Reson Med) Vol. 13 Issue 2 Pg. 204-15 (Feb 1990) ISSN: 0740-3194 [Print] UNITED STATES
PMID2314211 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Phosphorus
  • Animals
  • Coronary Circulation
  • Coronary Disease (metabolism, physiopathology)
  • Endocardium (metabolism)
  • Fourier Analysis
  • Magnetic Resonance Spectroscopy
  • Models, Cardiovascular
  • Models, Structural
  • Myocardium (metabolism)
  • Phosphorus
  • Swine

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: