Retrograde amnesia produced by intrastriatal atropine and its reversal by choline.

Abstract	A number of studies have shown that cholinergic blockade of the striatum produces amnesia. In the present experiment it was predicted that by increasing the synthesis of striatal acetylcholine such amnesic state would be prevented. Atropine was injected into the striatum of rats before training of passive avoidance; some of these rats were also injected, intrastriatally, with choline before testing the retention of the task. Atropine alone produced amnesia while the combination of treatments reversed this effect.
Authors	R Solana-Figueroa, R A Prado-Alcalá
Journal	Life sciences (Life Sci) Vol. 46 Issue 10 Pg. 679-86 ( 1990) ISSN: 0024-3205 [Print] Netherlands
PMID	2314189 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Atropine Choline Acetylcholine
Topics	Acetylcholine (biosynthesis) Amnesia (prevention & control) Amnesia, Retrograde (chemically induced, prevention & control) Analysis of Variance Animals Atropine (antagonists & inhibitors) Avoidance Learning (drug effects) Choline (pharmacology, therapeutic use) Corpus Striatum (drug effects) Drug Interactions Male Random Allocation Rats Rats, Inbred Strains

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