Instant dentin hypersensitivity relief of a single topical application of an in-office desensitizing paste containing 8% arginine and calcium carbonate: a split-mouth, randomized-controlled study.

Abstract

OBJECTIVE:

The aim of this study was to evaluate the clinical efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate relative to calcium carbonate alone in the reduction of dentin hypersensitivity in a randomized, double-blind, split-mouth clinical trial.

MATERIALS AND METHODS:

Sixty teeth (30 subjects) with an air blast hypersensitivity score of 2 or 3 (Schiff Cold Air Sensitivity Scale) were randomly assigned to one of two treatment groups: (1) test paste containing 8% arginine and calcium carbonate (elmex sensitive professional desensitizing paste) and (2) control paste: paris white (calcium carbonate). Tactile and air blast dentin hypersensitivity examinations were performed at baseline, immediately after paste application and 4 and 12 weeks later.

RESULTS:

A statistically significant difference in air blast (p = 0.001) and tactile (p = 0.047) hypersensitivity reduction over time was observed between the two therapy modes. After 12-weeks, statistically significant differences were indicated between the test and control group with respect to baseline-adjusted mean tactile (41.94%; p = 0.038) and air blast hypersensitivity scores (46.5%; p = 0.017).

CONCLUSIONS:

The tested in-office desensitizing paste containing 8.0% arginine and calcium carbonate provides significantly greater hypersensitivity relief compared to calcium carbonate alone.

• Authors: Ines Kapferer, Claudia Pflug, Irene Kisielewsky, Johannes Giesinger, Ulrike S Beier, Herbert Dumfahrt
• Journal: Acta odontologica Scandinavica (Acta Odontol Scand) 2013 May-Jul Vol. 71 Issue 3-4 Pg. 994-9 ISSN: 1502-3850 [Electronic] England
• PMID: 23140517 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Toothpastes
• Arginine
• Calcium Carbonate

Topics

• Administration, Topical
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Arginine (administration & dosage)
• Calcium Carbonate (administration & dosage)
• Dentin Sensitivity
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Office Visits
• Toothpastes
• Young Adult