Abstract |
Sweet'n low in stereo: A Wharton reaction was employed along with a diastereoselective palladium-catalyzed glycosylation and other post-glycosylation transformations to synthesize digitoxin analogues. Cytotoxic evaluation against a panel of cancer cell lines uncovered the stereochemical and substitutional limits of the C3'/C4'-hydroxy functionality in digitoxin monosaccharide.
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Authors | John W Hinds, Sean B McKenna, Ehesan U Sharif, Hua-Yu L Wang, Novruz G Akhmedov, George A O'Doherty |
Journal | ChemMedChem
(ChemMedChem)
Vol. 8
Issue 1
Pg. 63-9
(Jan 2013)
ISSN: 1860-7187 [Electronic] Germany |
PMID | 23139074
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Antineoplastic Agents
- Cardiotonic Agents
- Digitoxigenin
- Palladium
- Digitoxin
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Topics |
- Antineoplastic Agents
(chemical synthesis, chemistry, pharmacology)
- Cardiotonic Agents
(chemical synthesis, chemistry, pharmacology)
- Catalysis
- Cell Line, Tumor
- Digitoxigenin
(chemical synthesis, chemistry, pharmacology)
- Digitoxin
(analogs & derivatives, chemical synthesis, pharmacology)
- Drug Screening Assays, Antitumor
- Glycosylation
- Humans
- Neoplasms
(drug therapy)
- Palladium
(chemistry)
- Stereoisomerism
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