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The use of VP16 and cisplatin in the treatment of Merkel cell carcinoma.

Abstract
A 70-year-old male with regionally recurrent Merkel cell cancer obtained a complete remission with three cycles of VP16 and cisplatin. His response was consolidated with local radiation therapy. Two additional patients have been reported to have responded to the same combination. Chemotherapy consisting of either cyclophosphamide, vincristine, and doxorubicin or VP16 and cisplatin should be considered in locally recurrent Merkel cell cancer.
AuthorsM P Davis, E M Miller, R C Rau, O E Johnson, R A Naille, M J Crnkovich
JournalThe Journal of dermatologic surgery and oncology (J Dermatol Surg Oncol) Vol. 16 Issue 3 Pg. 276-8 (Mar 1990) ISSN: 0148-0812 [Print] United States
PMID2312900 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Etoposide
  • Cisplatin
Topics
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Carcinoma, Merkel Cell (drug therapy)
  • Cisplatin (administration & dosage)
  • Combined Modality Therapy
  • Etoposide (administration & dosage)
  • Humans
  • Male
  • Remission Induction
  • Skin Neoplasms (drug therapy)

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