Serum adiponectin in relation to race-ethnicity and vascular risk factors in the Northern Manhattan Study.

Abstract

BACKGROUND:

Population-based data on serum adiponectin levels, an adipocytokine secreted from adipose tissue, are lacking, particularly across race-ethnic groups. Studies have suggested an inverse association between adiponectin and vascular risk factors, but data are limited and inconsistent. We examined the cross-sectional association between adiponectin, vascular risk factors and race-ethnicity in the population-based Northern Manhattan Study (NOMAS).

METHODS:

Blood samples, anthropomorphics, and vascular risk factors were collected at baseline. Multivariable linear regression analysis was conducted with log-transformed adiponectin as the dependent variable.

RESULTS:

Adiponectin was measured among 2900 participants (age 69±10 years, body mass index (BMI) 28.0±5.6, 37% male, 21% white, 53% Hispanic, 24% black). The mean adiponectin was 11.4±6.2 μg/mL (median=9.8, range=2.1-53.3). After multivariable adjustment, adiponectin levels were greatest among whites, followed by Hispanics, and lowest among blacks. Lower adiponectin levels were observed in participants with the following characteristics: Male, former smoking, hypertension, diabetes, homeostasis model assessment of insulin resistance (HOMA-IR), metabolic syndrome, moderate alcohol use, elevated waist circumference, BMI, estimated glomerular filtration rate (eGFR), triglycerides, low-density lipoprotein cholesterol (LDL-C), lower high-density lipoprotein cholesterol (HDL-C), and younger age. Obesity was a stronger risk factor for decreased adiponectin among blacks than among whites or Hispanics. The associations for several vascular risk factors, including hypertension, triglycerides, and low HDL-C, with low adiponectin were stronger among individuals who were not obese than among those who were obese.

CONCLUSIONS:

Adiponectin levels were lower among blacks and Hispanics and among those with various vascular risk factors, and greater with older age. The association between BMI and adiponectin varied across race-ethnic groups. Investigation of whether differences in body fat distribution may explain race-ethnic differences in adiponectin is needed.

• Authors: Hannah Gardener, Milita Crisby, Charlotte Sjoberg, Barry Hudson, Ronald Goldberg, Armando J Mendez, Clinton B Wright, Tatjana Rundek, Mitchell S V Elkind, Ralph L Sacco
• Journal: Metabolic syndrome and related disorders (Metab Syndr Relat Disord) Vol. 11 Issue 1 Pg. 46-55 (Feb 2013) ISSN: 1557-8518 [Electronic] United States
• PMID: 23127161 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• ADIPOQ protein, human
• Adiponectin

Topics

• Adiponectin (blood)
• Aged
• Body Mass Index
• Cohort Studies
• Cross-Sectional Studies
• Ethnicity (statistics & numerical data)
• Female
• Humans
• Male
• Middle Aged
• New York City (epidemiology)
• Obesity (blood, complications, epidemiology, ethnology)
• Racial Groups (statistics & numerical data)
• Risk Factors
• Vascular Diseases (blood, epidemiology, ethnology)