Contribution of the spinal P2X7 receptors to bee venom-induced nociception and inflammation in conscious rats.

Abstract

Recently, P2X7 receptor (P2X7R) has been found to contribute to the development of inflammatory pain, however, the role of spinal P2X7R is not clear. The present study was designed to determine the roles of spinal P2X7R in the bee venom (BV) model, characterized by multiple pain-related behaviors and obvious inflammatory edema. We determined the effects of P2X7R antagonist A438790 on BV-induced PSN, mechanical allodynia and inflammatory swelling. Pre-treatment with intrathecal administration of A438079 significantly inhibited BV-induced PSN and mechanical allodynia in a dose-dependent manner, but had no effect on BV-induced inflammatory swelling. These data suggest that the activation of spinal P2X7Rs may play a key role in BV-induced nociception, but not inflammation.

• Authors: Zhong-He Zhou, Jian-Xiu Wang, Bao-Jun Liu, Man Li, Yao Lu, Hui-Sheng Chen
• Journal: Neuroscience letters (Neurosci Lett) Vol. 531 Issue 2 Pg. 145-8 (Dec 07 2012) ISSN: 1872-7972 [Electronic] Ireland
• PMID: 23123775 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Bee Venoms
• Receptors, Purinergic P2X7

Topics

• Animals
• Bee Venoms (toxicity)
• Hyperalgesia (chemically induced, metabolism)
• Inflammation (chemically induced, metabolism)
• Male
• Pain (chemically induced, metabolism)
• Pain Threshold (drug effects, physiology)
• Rats
• Rats, Sprague-Dawley
• Receptors, Purinergic P2X7 (metabolism)
• Spinal Cord (metabolism)