A double-blind controlled field trial of doxycycline and albendazole in combination for the treatment of bancroftian filariasis in India.

Abstract

In a placebo controlled field trial, the effects of doxycycline (200mg/day) for 23 days followed by doxycycline (200mg/day) in combination with albendazole (ABZ) (400mg/day) for 7 days on depletion of Wolbachia endobacteria from Wuchereria bancrofti and microfilaricidal activity were studied in 68 patients (34 males and 34 females) from West Bengal, India. The drugs in combination (i.e., doxycycline+ABZ) provided the best efficacy by totally eliminating the circulating microfilaria (mf) (in 42% cases) on day 365 with (99.8%, P<0.05) suppression even on day 365 post-treatment compared to both exclusive doxycycline (69%, P<0.05) and ABZ (89%, P<0.05) groups. Thus, our results have established that a 30-day course of doxycycline in combination with a 7-day course of ABZ is sufficient to ensure long-term reduction in mf level by depleting Wolbachia from worm tissues. Doxycycline combined with ABZ led to a greater reduction in mf density in blood at 4 months (post-treatment) in comparison to doxycycline or ABZ alone. There were significant differences between the three treatments after 12 months (post-treatment). Further, the impact of a 7-day regimen of ABZ was surprisingly good in reducing mf compared to doxycycline-alone group. Adverse reactions were mild. A 30-day course of doxycycline and ABZ in combination is a safe and well-tolerated treatment for lymphatic filariasis with significant activity against microfilaremia.

• Authors: Prajna Gayen, Ananya Nayak, Prasanta Saini, Niladri Mukherjee, Sudipta Maitra, Prasanta Sarkar, Santi P Sinha Babu
• Journal: Acta tropica (Acta Trop) Vol. 125 Issue 2 Pg. 150-6 (Feb 2013) ISSN: 1873-6254 [Electronic] Netherlands
• PMID: 23123345 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Anthelmintics
• Anti-Bacterial Agents
• Albendazole
• Doxycycline

Topics

• Adolescent
• Adult
• Aged
• Albendazole (administration & dosage, therapeutic use)
• Animals
• Anthelmintics (administration & dosage, therapeutic use)
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Bacterial Load
• Double-Blind Method
• Doxycycline (administration & dosage, therapeutic use)
• Drug Administration Schedule
• Drug Therapy, Combination
• Elephantiasis, Filarial (blood, drug therapy, parasitology)
• Female
• Humans
• India
• Logistic Models
• Male
• Middle Aged
• Parasite Load
• Time Factors
• Wolbachia (drug effects)
• Wuchereria bancrofti (drug effects, microbiology)
• Young Adult