Metformin decreases serum 8-hydroxy-2'-deoxyguanosine levels in polycystic ovary syndrome.

Abstract

OBJECTIVE:

To learn whether metformin treatment affects oxidative stress as measured by serum concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG).

DESIGN:

Double-blind, randomized, placebo-controlled trial.

SETTING:

University outpatient clinic.

PATIENT(S):

The study cohort consisted of 50 obese women (body mass index [BMI] ≥ 27 kg/m(2)) and 60 nonobese patients (BMI <27 kg/m(2)), mean age was 27.7 ± 4.0 SD years.

INTERVENTION(S):

Randomization to receive metformin or placebo for 3 months.

MAIN OUTCOME MEASURE(S):

Serum levels of 8-OHdG before and after medical treatment.

RESULT(S):

The levels of 8-OHdG were equal at baseline in the placebo and metformin groups. Obese women had higher baseline serum concentrations of 8-OHdG. Levels of 8-OHdG were statistically significantly reduced with metformin treatment, especially in obese patients with polycystic ovary syndrome. This study was a secondary subanalysis of a previously conducted prospective multicenter, randomized, placebo-controlled study on the effects of metformin on miscarriage, pregnancy, and miscarriage rates.

CONCLUSION(S):

Metformin treatment, compared with placebo, statistically significantly decreased 8-OHdG levels in women with polycystic ovary syndrome.

CLINICAL TRIAL REGISTRATION NUMBER:

NCT00994812.

• Authors: Henri Sova, Ulla Puistola, Laure Morin-Papunen, Peeter Karihtala
• Journal: Fertility and sterility (Fertil Steril) Vol. 99 Issue 2 Pg. 593-8 (Feb 2013) ISSN: 1556-5653 [Electronic] United States
• PMID: 23122829 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Chemical References

• 8-hydroxy-2'-deoxyadenosine
• Biomarkers
• Deoxyadenosines
• Hypoglycemic Agents
• Metformin

Topics

• Adult
• Biomarkers (blood)
• Deoxyadenosines (blood)
• Double-Blind Method
• Down-Regulation (drug effects)
• Female
• Humans
• Hypoglycemic Agents
• Metformin (therapeutic use)
• Polycystic Ovary Syndrome (blood, drug therapy)
• Treatment Outcome