Fresh frozen plasma for progressive and refractory angiotensin-converting enzyme inhibitor-induced angioedema.

Abstract

BACKGROUND:

Angioedema secondary to angiotensin-converting enzyme inhibitors (ACEI) is a commonly encountered problem in the Emergency Department (ED). The treatment of ACEI-induced edema with conventional methods such as epinephrine, steroids, and antihistamines is usually not effective. There is limited experience using bradykinin receptor blockers and fresh frozen plasma (FFP) as a treatment modality for ACEI-induced angioedema.

OBJECTIVE:

To emphasize alternative treatment option for ACEI-induced angioedema in the ED.

CASE REPORTS:

We report a case series of progressive and refractory presumed ACEI-induced angioedema that all improved in temporal association with administration of FFP, with a brief review of the literature.

CONCLUSION:

There was a temporal association between the administration of FFP and improvement in angioedema in seven cases of presumed ACEI-induced angioedema that were refractory to antihistamines, corticosteroids, and epinephrine.

• Authors: Getaw Worku Hassen, Hossein Kalantari, Monica Parraga, Roger Chirurgi, Carlos Meletiche, Christopher Chan, Jacque Ciarlo, Farhad Gazi, Christopher Lobaito, Siamak Tadayon, Selamawit Yemane, Carolina Velez
• Journal: The Journal of emergency medicine (J Emerg Med) Vol. 44 Issue 4 Pg. 764-72 (Apr 2013) ISSN: 0736-4679 [Print] United States
• PMID: 23114109 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: Published by Elsevier Inc.

Chemical References

• Angiotensin-Converting Enzyme Inhibitors

Topics

• Aged
• Angioedema (chemically induced, drug therapy)
• Angiotensin-Converting Enzyme Inhibitors (adverse effects)
• Blood Transfusion (methods)
• Female
• Humans
• Male
• Middle Aged
• Plasma
• Treatment Outcome