Abstract | BACKGROUND:
Colon cancer is one of the major causes of death in the Western world. Early detection significantly improves long-term survival for patients with the disease. Near- infrared (NIR) fluorescent nanoparticles hold great promise as contrast agents for tumor detection. NIR offers several advantages for bioimaging compared with fluorescence in the visible spectrum, ie, lower autofluorescence of biological tissues, lower absorbance, and consequently deeper penetration into biomatrices. METHODS AND RESULTS: CONCLUSION: Conjugation of peanut agglutinin or αCEA to the nanoparticles significantly increased the fluorescence intensity of the tagged colon tumor tissues relative to the nonconjugated nanoparticles.
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Authors | Enav Corem-Salkmon, Benny Perlstein, Shlomo Margel |
Journal | International journal of nanomedicine
(Int J Nanomedicine)
Vol. 7
Pg. 5517-27
( 2012)
ISSN: 1178-2013 [Electronic] New Zealand |
PMID | 23112575
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contrast Media
- Ferric Compounds
- ferric oxide
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Topics |
- Animals
- Cell Line, Tumor
- Colorectal Neoplasms
(pathology)
- Contrast Media
(chemical synthesis)
- Drug Design
- Ferric Compounds
(chemistry)
- Humans
- Infrared Rays
- Metal Nanoparticles
(chemistry)
- Mice
- Mice, Nude
- Microscopy, Fluorescence
(methods)
- Reproducibility of Results
- Sensitivity and Specificity
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