Anti‑livin antibodies in Hashimoto thyroiditis.

Abstract

INTRODUCTION:

Livin belongs to the family of apoptosis inhibitors. High livin expression is observed in malignancies of the gastrointestinal tract, lungs, breast, and kidneys, but it is not present in differentiated adult tissues. In some malignant processes, anti‑livin antibodies are present.

OBJECTIVES:

The aim of the study was to evaluate the prevalence of anti‑livin antibodies in Hashimoto thyroiditis, a disease characterized by rapid and widespread thyrocyte apoptosis.

PATIENTS AND METHODS:

The study comprised 65 women with Hashimoto thyroiditis and the control group of 40 healthy women. In the majority of the patients, clinical manifestations of hypothyroidism were observed; all patients had high levels of serum antithyroid peroxidase antibodies. A solid‑phase radioimmunoassay in livin‑coated polyethylene tubes using 125I-labeled protein A was used to determine anti-livin antibodies.

RESULTS:

Significant amounts of anti-livin antibodies were reported in 18 patients (26.8%); 3 patients (4.6%) had borderline antibody levels; while in controls only 1 patient was positive (2.5%, P <0.0001).

CONCLUSIONS:

In Hashimoto thyroiditis, an autoimmune process is more general and involves numerous autoantibodies including an antibody against apoptosis inhibitor - livin. Anti‑livin antibodies cannot serve only as a marker of malignancy because they are also present in autoimmune processes.

• Authors: Aleksandra Baumann-Antczak, Jerzy Kosowicz, Hanna Zamysłowska, Marek Ruchała
• Journal: Polskie Archiwum Medycyny Wewnetrznej (Pol Arch Med Wewn) Vol. 122 Issue 11 Pg. 527-30 ( 2012) Poland
• PMID: 23111654 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adaptor Proteins, Signal Transducing
• Antibodies, Anti-Idiotypic
• BIRC7 protein, human
• Biomarkers
• Inhibitor of Apoptosis Proteins
• Neoplasm Proteins

Topics

• Adaptor Proteins, Signal Transducing (blood)
• Adult
• Antibodies, Anti-Idiotypic (blood)
• Biomarkers (blood)
• Female
• Hashimoto Disease (immunology)
• Humans
• Inhibitor of Apoptosis Proteins (blood)
• Neoplasm Proteins (blood)
• Predictive Value of Tests
• Radioimmunoassay
• Severity of Illness Index
• Young Adult