Abstract | INTRODUCTION: OBJECTIVES: PATIENTS AND METHODS: RESULTS: Lysosomal exoglycosidases and CD have similar specific activity in colon adenocarcinoma tissue and urine, which is higher than their activity in serum (with the exception of the highest specific activity of CD in urine). A positive correlation was observed between the specific activity of CD and that of HEX, HEX A, FUC, and MAN in the carcinoma tissue and urine as well as between CD and GAL in the urine of patients with colon adenocarcinoma. Negative correlations were observed between protein levels and the specific activity of HEX, HEX A, FUC, MAN, and CD in the carcinoma tissue and urine, and between protein levels and GAL in urine. CONCLUSIONS:
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Authors | Napoleon Waszkiewicz, Beata Zalewska-Szajda, Sławomir D Szajda, Alina Kępka, Magdalena Waszkiewicz, Wiesława Roszkowska-Jakimiec, Marzena Wojewódzka-Żeleźniakowicz, Anna J Milewska, Jacek Dadan, Agata Szulc, Krzysztof Zwierz, Jerzy R Ladny |
Journal | Polskie Archiwum Medycyny Wewnetrznej
(Pol Arch Med Wewn)
Vol. 122
Issue 11
Pg. 551-6
( 2012)
Poland |
PMID | 23111620
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Isoenzymes
- beta-Galactosidase
- alpha-Mannosidase
- Hexosaminidase A
- Hexosaminidase B
- beta-N-Acetylhexosaminidases
- Cathepsin D
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Topics |
- Adenocarcinoma
(enzymology, metabolism)
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Cathepsin D
(metabolism)
- Colonic Neoplasms
(enzymology, metabolism)
- Female
- Hexosaminidase A
(metabolism)
- Hexosaminidase B
(metabolism)
- Humans
- Isoenzymes
(metabolism)
- Lysosomes
(metabolism)
- Male
- Middle Aged
- Predictive Value of Tests
- Sensitivity and Specificity
- Serum
(metabolism)
- alpha-Mannosidase
(metabolism)
- beta-Galactosidase
(metabolism)
- beta-N-Acetylhexosaminidases
(metabolism)
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