Abstract | BACKGROUND: OBJECTIVES: This study was performed to compare the ameliorating effects of K-134 and cilostazol on brain damage in an experimental photothrombotic cerebral infarction model. METHODS AND RESULTS: We investigated the effects of oral preadministration of PDE3 inhibitors in a rat stroke model established by photothrombotic middle cerebral artery (MCA) occlusion. K-134 significantly prolonged MCA occlusion time at doses >10 mg/kg, and reduced cerebral infarct size at 30 mg/kg in the stroke model (nā=ā12, 87.5±5.6 vs. 126.8±7.5 mm(3), P<0.01), indicating its potent antithrombotic effect. On the other hand, the effects of cilostazol on MCA occlusion time and cerebral infarct size are relatively weak even at the high dosage of 300 mg/kg. Furthermore, K-134 blocked rat platelet aggregation more potently than cilostazol in vitro. Also in an arteriovenous shunt thrombosis model, K-134 showed an antithrombotic effect greater than cilostazol. CONCLUSIONS: These findings suggest that K-134, which has strong antithrombotic activity, is a promising drug for prevention of cerebral infarction associated with platelet hyperaggregability.
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Authors | Hideo Yoshida, Yuka Ashikawa, Shinsuke Itoh, Takashi Nakagawa, Akimune Asanuma, Sohei Tanabe, Yoshihiro Inoue, Hiroyoshi Hidaka |
Journal | PloS one
(PLoS One)
Vol. 7
Issue 10
Pg. e46432
( 2012)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23110051
(Publication Type: Journal Article)
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Chemical References |
- Phosphodiesterase 3 Inhibitors
- Quinolines
- Urea
- OPC 33509
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Topics |
- Animals
- Brain
(drug effects, metabolism, pathology)
- Cerebral Infarction
(drug therapy, pathology)
- Male
- Mice
- Mice, Inbred ICR
- Phosphodiesterase 3 Inhibitors
(therapeutic use)
- Quinolines
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Thrombosis
(prevention & control)
- Urea
(analogs & derivatives, therapeutic use)
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