Abstract | BACKGROUND: METHODS: Biopsies were obtained from lesions of twenty proven cases of L. major induced cutaneous leishmaniasis. IL-10 and TGF-β positive cells were detected by immunofluorescence staining of frozen sections and compared between two groups of patients with early and late lesions. RESULTS: The mean percentage of IL-10 positive cells were significantly (P= 0.035) higher in late lesions (0.51±0.24) than early ones (0.15±0.07). Similar results were obtained for TGF-β with mean percentages of 0.16±0.05 and 0.53±0.28 in early and late lesions respectively (P= 0.008). CONCLUSION:
IL-10 and TGF-β are present in lesions of L. major induced cutaneous leishmaniasis and contribute to the pathogenesis of long lasting disease forms.
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Authors | Sh Hejazi, Sg Hoseini, Sh Javanmard, Sh Zarkesh, A Khamesipour |
Journal | Iranian journal of parasitology
(Iran J Parasitol)
Vol. 7
Issue 3
Pg. 16-23
( 2012)
ISSN: 2008-238X [Electronic] Iran |
PMID | 23109957
(Publication Type: Journal Article)
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