Abstract |
Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/ obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs and their interactions with overweight/ obesity on blood pressure levels. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor ( LDL-R) AvaII hepatic lipase gene (LIPC) -250G > A, endothelial lipase gene (LIPG) 584C > T, methylenetetrahydrofolate reductase (MTHFR) 677C > T, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP) rs3757354, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T > C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 978 normal weight and 751 overweight/obese subjects. The interactions were detected by factorial regression analysis. The genotypes of ACAT-1 AC, LIPC GA and AA, and SCARB1 TT; LDL-R A-A- and LIPC GA; and SCARB1 TT were interacted with overweight/ obesity to increase systolic, diastolic blood pressure (SBP, DBP) and pulse pressure (PP) levels; respectively. The genotypes of ACAT-1 CC; ACAT-1 AA and CC were interacted with overweight/ obesity to decrease SBP, PP levels (p < 0.01-0.001); respectively. The differences in blood pressure levels between normal weight and overweight/obese subjects might partly result from different interactions of several SNPs and overweight/ obesity.
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Authors | Rui-Xing Yin, Dong-Feng Wu, Lynn Htet Htet Aung, Ting-Ting Yan, Xiao-Li Cao, Xing-Jiang Long, Lin Miao, Wan-Ying Liu, Lin Zhang, Meng Li |
Journal | International journal of molecular sciences
(Int J Mol Sci)
Vol. 13
Issue 9
Pg. 12062-12081
( 2012)
ISSN: 1422-0067 [Electronic] Switzerland |
PMID | 23109900
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Adult
- Blood Pressure
(genetics)
- China
(epidemiology)
- Epistasis, Genetic
- Female
- Genotype
- Humans
- Lipid Metabolism
(genetics)
- Male
- Middle Aged
- Obesity
(epidemiology, genetics)
- Polymorphism, Single Nucleotide
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