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Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels.

Abstract
Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs and their interactions with overweight/obesity on blood pressure levels. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaII hepatic lipase gene (LIPC) -250G > A, endothelial lipase gene (LIPG) 584C > T, methylenetetrahydrofolate reductase (MTHFR) 677C > T, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP) rs3757354, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T > C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 978 normal weight and 751 overweight/obese subjects. The interactions were detected by factorial regression analysis. The genotypes of ACAT-1 AC, LIPC GA and AA, and SCARB1 TT; LDL-R A-A- and LIPC GA; and SCARB1 TT were interacted with overweight/obesity to increase systolic, diastolic blood pressure (SBP, DBP) and pulse pressure (PP) levels; respectively. The genotypes of ACAT-1 CC; ACAT-1 AA and CC were interacted with overweight/obesity to decrease SBP, PP levels (p < 0.01-0.001); respectively. The differences in blood pressure levels between normal weight and overweight/obese subjects might partly result from different interactions of several SNPs and overweight/obesity.
AuthorsRui-Xing Yin, Dong-Feng Wu, Lynn Htet Htet Aung, Ting-Ting Yan, Xiao-Li Cao, Xing-Jiang Long, Lin Miao, Wan-Ying Liu, Lin Zhang, Meng Li
JournalInternational journal of molecular sciences (Int J Mol Sci) Vol. 13 Issue 9 Pg. 12062-12081 ( 2012) ISSN: 1422-0067 [Electronic] Switzerland
PMID23109900 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Topics
  • Adolescent
  • Adult
  • Blood Pressure (genetics)
  • China (epidemiology)
  • Epistasis, Genetic
  • Female
  • Genotype
  • Humans
  • Lipid Metabolism (genetics)
  • Male
  • Middle Aged
  • Obesity (epidemiology, genetics)
  • Polymorphism, Single Nucleotide

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