HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Chemotherapy and cognitive complaints in women with breast cancer.

AbstractBACKGROUND:
Results of existing studies are inconclusive concerning the relationship between chemotherapy and subjective cognitive functioning (SCF). The aim of this study was to evaluate SCF of breast cancer (BC) patients and to find predictors of impaired SCF. Both satisfaction and frequency of complaints about SCF were measured.
METHODS:
BC patients who were about to receive chemotherapy (N = 74) and patients with a benign breast disease (BBD) (N = 63) participated. Before chemotherapy started (Time 1) and 3 months after ending chemotherapy (and at comparable moments for the BBD group) (Time 2), women completed validated questionnaires concerning the frequency of complaints and satisfaction with SCF, fatigue, perceived stress, anxiety, and depressive symptoms.
RESULTS:
No differences were found between the BBD and BC patients concerning the frequency of complaints about SCF across time. Satisfaction with SCF decreased across time in BC patients but remained stable across time in BBD patients (p < 0.001; p = 0.003 after controlling for state anxiety and perceived stress). Correlation coefficients between the satisfaction and the frequency of complaints about SCF ranged between -0.26 and -0.49. Depressive symptoms and satisfaction with SCF (Time 1) predicted the frequency of complaints about SCF (Time 2). Diagnosis, frequency of complaints about SCF, and state anxiety (Time 1) predicted satisfaction with SCF (Time 2).
CONCLUSIONS:
BC patients do not differ in the frequency of complaints about SCF compared with BBD patients, but their satisfaction with SCF decreased after treatment. Psychological factors predicted the frequency of complaints about SCF. Psychological factors and diagnosis predicted satisfaction with SCF.
AuthorsMarleen J J Pullens, Jolanda De Vries, Laurence J C Van Warmerdam, Marieke A Van De Wal, Jan A Roukema
JournalPsycho-oncology (Psychooncology) Vol. 22 Issue 8 Pg. 1783-9 (Aug 2013) ISSN: 1099-1611 [Electronic] England
PMID23109296 (Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 John Wiley & Sons, Ltd.
Chemical References
  • Antineoplastic Agents
Topics
  • Adult
  • Aged
  • Antineoplastic Agents (adverse effects, therapeutic use)
  • Anxiety (psychology)
  • Anxiety Disorders (diagnosis, psychology)
  • Breast Diseases (complications, diagnosis, psychology, therapy)
  • Breast Neoplasms (complications, drug therapy, psychology)
  • Cognition (drug effects)
  • Cognition Disorders (diagnosis, epidemiology, etiology, psychology)
  • Depression (psychology)
  • Fatigue (diagnosis, psychology)
  • Female
  • Humans
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Staging
  • Netherlands (epidemiology)
  • Personal Satisfaction
  • Prevalence
  • Prospective Studies
  • Quality of Life (psychology)
  • Regression Analysis
  • Surveys and Questionnaires

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: