Comparing beneficial effects of inhaled nitric oxide to L-arginine in necrotizing enterocolitis model in neonatal rats.

Abstract

OBJECTIVE:

Necrotizing enterocolitis (NEC) is a common and devastating gastrointestinal condition of neonatal infants. The pathophysiology of NEC remains poorly understood. We tried to evaluate the effectiveness of inhaled NO compared to L-arginine usage in necrotizing enterocolitis model in rats.

MATERIAL-METHODS:

46 newborn pups from 4 time-mated Sprague-Dawley pregnant rats were divided equally into 4 groups as follows: NEC (subjected to NEC), NEC + L-arginine, NEC + inhaled NO and control.

RESULTS:

SOD, GSH-Px and NOx levels were significantly higher and MDA levels were significantly lower in NEC + inhaled NO group compared to NEC + L-arginine group. There was significantly lower intestinal injury and apoptosis index scoring in NEC + inhaled NO group compared to NEC + L-arginine group.

CONCLUSION:

We think that inhaled NO can be used as a novel therapeutic agent like L-arginine in NEC, like using in pulmonary hypertention in newborns but much more studies are needed.

• Authors: Ferhat Çekmez, Tarık Purtuloğlu, Gokhan Aydemir, Secil Aydinoz, Kürşat Fidancı, Abdülbaki Karaoğlu, Oğuzhan Babacan, Fuat Emre Canpolat, Merih Cetinkaya, Turan Tunc, Selami Süleymanoglu
• Journal: Pediatric surgery international (Pediatr Surg Int) Vol. 28 Issue 12 Pg. 1219-24 (Dec 2012) ISSN: 1437-9813 [Electronic] Germany
• PMID: 23108981 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Nitric Oxide
• Arginine

Topics

• Administration, Inhalation
• Animals
• Animals, Newborn
• Arginine (therapeutic use)
• Disease Models, Animal
• Enterocolitis, Necrotizing (drug therapy)
• Nitric Oxide (administration & dosage)
• Rats
• Rats, Sprague-Dawley