HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Assessing oxazole bioisosteres as mutasynthons on the rhizoxin assembly line.

Abstract
Chain armor against tumor cells: The oxazole side chain in the antimitotic agent rhizoxin S2 (1) was successfully replaced through mutasynthesis by using an engineered mutant impaired in heterocyclization. Incorporation of 12 non-natural surrogates into fully processed rhizoxin analogues revealed a remarkable substrate flexibility of the PKS-NRPS hybrid.
AuthorsBjörn Kusebauch, Nicole Brendel, Heike Kirchner, Hans-Martin Dahse, Christian Hertweck
JournalChembiochem : a European journal of chemical biology (Chembiochem) Vol. 12 Issue 15 Pg. 2284-8 (Oct 17 2011) ISSN: 1439-7633 [Electronic] Germany
PMID23106078 (Publication Type: Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Macrolides
  • Oxazoles
  • Polyketide Synthases
  • rhizoxin
  • Peptide Synthases
Topics
  • Amino Acid Sequence
  • Antibiotics, Antineoplastic (chemistry, metabolism)
  • Burkholderia (chemistry, enzymology, genetics, metabolism)
  • Genes, Fungal
  • Genetic Loci
  • Macrolides (chemistry, metabolism)
  • Molecular Sequence Data
  • Mutation
  • Oxazoles (chemistry, metabolism)
  • Peptide Synthases (genetics, metabolism)
  • Polyketide Synthases (genetics, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: