Abstract | PURPOSE: PATIENTS AND METHODS: From September 2002 to September 2004, a total of 24 intraluminal brachytherapy applications were carried out on 12 lung transplant patients in 15 different locations. A single dose of 3 Gy was calculated at a 5-mm distance from the catheter surface; the target volume included a stenosis plus safety interval of 0.5-1.0 cm. RESULTS: All patients had a mean 10.6 local interventions ( Argon plasma coagulation, balloon dilatations, stenting) over 4.4 months before the first application of endobronchial brachytherapy, with a mean amount of 2.4 applications per month. The mean forced expiratory volume in 1 s (FEV1) was 2,219 ml in the 3 months before application of brachytherapy. After endobronchial brachytherapy, all patients experienced improvement in clinical status and respiratory function. The mean level of FEV1 in the 3 months after application was 2,435 ml (p = 0.02), and the number of invasive interventions dropped to a mean rate of 5.2 interventions in the 5.1 months after the first intervention, with an amount of 1 application per month. No treatment-related complications were seen. Four patients were treated twice, 1 patient three times, and 1 patient four times at the same localization. CONCLUSIONS: Recurrent symptomatic benign airway obstruction from hyperplastic tissue in the bronchus after lung transplantation can be successfully treated with intraluminal high-dose-rate brachytherapy with a dose of 3 Gy at a 5-mm distance from the catheter surface and a longitudinal safety margin of 1 cm.
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Authors | A Meyer, A Warszawski-Baumann, R Baumann, J H Karstens, H Christiansen, J Gottlieb, T Welte |
Journal | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
(Strahlenther Onkol)
Vol. 188
Issue 12
Pg. 1085-90
(Dec 2012)
ISSN: 1439-099X [Electronic] Germany |
PMID | 23104520
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adult
- Aged
- Airway Obstruction
(prevention & control, radiotherapy)
- Brachytherapy
(methods)
- Bronchoscopy
- Combined Modality Therapy
- Dilatation
- Female
- Forced Expiratory Volume
(radiation effects)
- Humans
- Lung Transplantation
- Male
- Middle Aged
- Postoperative Complications
(prevention & control, radiotherapy)
- Radiotherapy Dosage
- Retreatment
- Secondary Prevention
- Young Adult
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