Abstract |
The duration of antimicrobial prophylaxis in gastric cancer surgery is not yet established. This prospective randomized study was performed to confirm the noninferiority of single-dose versus multiple-dose antimicrobial prophylaxis in terms of the incidence of surgical-site infection in gastric cancer surgery. Three hundred twenty-five patients undergoing elective resection for gastric cancer were randomized to receive only single-dose cefazolin (1 g) during surgery (single-dose group) or an additional 5 doses every 12 hours postoperatively (multiple-dose group). The overall incidence of surgical-site infections was 9.1% in the single-dose group and 6.2% in the multiple-dose group [difference (95% confidence interval): -2.9% (-5.9%-0.0%)]. Multivariate logistic regression analysis identified blood loss, being overweight, and advanced age as significant independent risk factors for surgical-site infection. Single-dose antimicrobial prophylaxis seemed to be acceptable, and choosing multiple-dose prophylaxis may have little impact on the prevention of surgical-site infections in elective gastric cancer surgery.
|
Authors | Norihiro Haga, Hideyuki Ishida, Toru Ishiguro, Kensuke Kumamoto, Keiichiro Ishibashi, Yoshitaka Tsuji, Tatsuya Miyazaki |
Journal | International surgery
(Int Surg)
2012 Apr-Jun
Vol. 97
Issue 2
Pg. 169-76
ISSN: 2520-2456 [Electronic] Italy |
PMID | 23102084
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Anti-Bacterial Agents
- Cefazolin
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(therapeutic use)
- Antibiotic Prophylaxis
(methods)
- Cefazolin
(therapeutic use)
- Drug Administration Schedule
- Elective Surgical Procedures
- Female
- Follow-Up Studies
- Gastrectomy
- Humans
- Incidence
- Intraoperative Care
(methods)
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Postoperative Care
(methods)
- Prospective Studies
- Risk Factors
- Stomach Neoplasms
(surgery)
- Surgical Wound Infection
(epidemiology, etiology, prevention & control)
- Treatment Outcome
|