[Effect of Gorei-san with tranexamic acid for preventing recurrence of chronic subdural hematoma].

Abstract

OBJECT:

Chronic subdural hematoma is often seen in elderly patients. One burr hole surgery with subdural drainage has been performed and prognosis is good, but the recurrence rate is still about 10%. To prevent the recurrence, we used Kampo-medicine Gorei-san with tranexamic acid after surgery. The purpose of this study is to investigate if the recurrence is able to prevent by using these drugs.

METHODS:

From January 2008 to December 2010, 199 consecutive cases with chronic subdural hematoma were examined at Nagatomi Neurosurgical Hospital. Patients were divided into four groups according to the administered drugs; Gorei-san, tranexamic acid, Gorei-san with tranexamic acid and no drug groups. The recurrence rate was compared between each group. The chi-square test was performed as a statistical analysis.

RESULTS:

In all patients, the mean age was 77.7±10.5 years. There were 140 males and 59 females. Overall recurrence rate was 7.0%. Each recurrence rate was 8.3% in the Gorei-san administration group, and 10.9% in the tranexamic acid group, and 2.9% in Gorei-san with tranexamic acid group, and 5.7% in the no-drug group. There was no significant difference between the four groups in statistical analysis.

CONCLUSIONS:

Gorei-san with the tranexamic acid administration group had the minimum recurrence. There was no significant difference but these drugs would be preventable recurrence of chronic subdural hematoma. We need to accumulate more cases as a prospective study in the future.

• Authors: Yukihiro Wakabayashi, Masanori Yamashita, Tomoshige Asano, Akira Yamada, Hiroyuki Kenai, Yayoi Kondoh, Yuzo Hori, Hirofumi Nagatomi
• Journal: No shinkei geka. Neurological surgery (No Shinkei Geka) Vol. 40 Issue 11 Pg. 967-71 (Nov 2012) ISSN: 0301-2603 [Print] Japan
• PMID: 23100384 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• gorei-san
• Tranexamic Acid

Topics

• Aged
• Aged, 80 and over
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Hematoma, Subdural, Chronic (drug therapy, surgery)
• Humans
• Male
• Medicine, Kampo
• Middle Aged
• Secondary Prevention
• Tranexamic Acid (therapeutic use)
• Treatment Outcome