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The influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on hematological parameters during experimentally induced pleuritis in rats.

Abstract
Proper functioning of homeostatic mechanisms is characteristic for every healthy organism and enables adapting to environmental changes. These complicated systematic reactions can neutralize the harmful stress factors leading to various inflammatory reactions. The aim of this study was to determine dynamic changes in the inflammatory reaction after single 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administration of 5 μg/kg body weight into rats with experimentally induced pleuritis. These changes were observed by monitoring the hematological blood parameters during inflammation. The obtained results proved that dioxins contribute to various changes in the character of the inflammatory response. TCDD administration before pleuritis initiation caused an increase of lymphocytes and significant decrease of the number of neutrophils during inflammation. The current study proved that administration of low TCDD dose (seven times lower than used in other studies) can cause thymus, spleen, or lymphatic gland atrophy. This finding indicates the toxic influence of small TCDD dose especially on the immune system.
AuthorsIreneusz Całkosiński, Joanna Rosińczuk-Tonderys, Justyna Bazan, Katarzyna Dzierzba, Monika Całkosińska, Jacek Majda, Maciej Dobrzyński, Agnieszka Bronowicka-Szydełko
JournalInflammation (Inflammation) Vol. 36 Issue 2 Pg. 387-404 (Apr 2013) ISSN: 1573-2576 [Electronic] United States
PMID23100032 (Publication Type: Journal Article)
Chemical References
  • Hemoglobins
  • Polychlorinated Dibenzodioxins
  • Carrageenan
Topics
  • Animals
  • Atrophy (chemically induced)
  • Basophils (drug effects)
  • Blood Cell Count
  • Blood Platelets (drug effects)
  • Carrageenan
  • Eosinophils (drug effects)
  • Erythrocytes (drug effects)
  • Female
  • Hematocrit
  • Hemoglobins (analysis)
  • Inflammation (chemically induced)
  • Lymphocyte Count
  • Lymphocytes (drug effects)
  • Neutrophils (drug effects)
  • Platelet Count
  • Pleurisy (blood)
  • Polychlorinated Dibenzodioxins (administration & dosage, toxicity)
  • Rats

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