Serum oncofetal fibronectin (onfFN) mRNA in differentiated thyroid carcinoma (DTC): large overlap between disease-free and metastatic patients.

Abstract

AIM:

This study assessed if onfFN mRNA in the peripheral blood of patients with DTC can identify individuals with metastatic disease.

METHODS:

Comparison of onfFN mRNA was made among 3 groups: disease-free, lymph node metastasis, and distant metastasis using real-time RT-PCR on 5 ml blood samples from each DTC patient.

RESULTS:

Fifty-one patients were included: 30 (59%) were disease-free; 7 (13.7%) had lymph node metastasis; and 14 (27.5%) had distant metastasis. OnfFN mRNA levels in the 3 groups were significantly different (P=0.001) but with a large overlap and the expression being highest in the disease-free group. Subgroup analysis of the metastatic groups did not show any effect of age, cell type, and serum TSH, Tg, and antiTg on onfFN mRNA. The within-run and between-run root mean square coefficients of variations were <2%.

CONCLUSION:

OnfFN mRNA in patients with DTC cannot identify those with metastatic disease.

• Authors: Chanika Sritara, Putthiporn Charoenphun, Mathurose Ponglikitmongkol, Suchawadee Musikarat, Chirawat Utamakul, Payap Chokesuwattanasakul, Ammarin Thakkinstian
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 13 Issue 8 Pg. 4203-8 ( 2012) ISSN: 2476-762X [Electronic] Thailand
• PMID: 23098431 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fibronectins
• RNA, Messenger
• oncofetal fibronectin
• Thyroglobulin

Topics

• Adenocarcinoma, Follicular (blood, genetics, secondary)
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Papillary (blood, genetics, secondary)
• Cell Differentiation
• Child
• Female
• Fibronectins (blood, genetics)
• Follow-Up Studies
• Humans
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Recurrence, Local (blood, genetics, pathology)
• Neoplasm Staging
• Prognosis
• RNA, Messenger (genetics)
• Real-Time Polymerase Chain Reaction
• Reverse Transcriptase Polymerase Chain Reaction
• Thyroglobulin (blood)
• Thyroid Neoplasms (blood, genetics, pathology)
• Young Adult