[A syndrome of chronic ataxic polyneuropathy, ophtalmoplegia, IgM paraprotein, cold agglutinins and anti-disialosyl antibodies can cause diplopia in patients with chronic sensory polyneuropathy].

Abstract

CANOMAD is a rare syndrome of chronic ataxic polyneuropathy, ophtalmoplegia, IgM paraprotein, cold agglutinins and anti-disialosyl antibodies. We present a case of a 65-year-old woman with clinical and electrophysiological features of chronic sensory polyneuropathy and diplopia. Serum samples from the patient contained IgM paraprotein and anti-GM2-antibodies. Treatment with intravenous immunoglobulins resulted in an improvement of the patient's diplopia and polyneuropathy. The case shows the importance of considering CANOMAD as a cause of diplopia in patients with chronic sensory polyneuropathy.

• Authors: Eva Brøsted Kolmos, Marie Moth Henriksen, Niels Abildgaard, Søren Hein Sindrup
• Journal: Ugeskrift for laeger (Ugeskr Laeger) Vol. 174 Issue 43 Pg. 2635-6 (Oct 22 2012) ISSN: 1603-6824 [Electronic] Denmark
• Vernacular Title: Monoklonal gammopati af ukendt signifikans kan medføre polyneuropati og oftalmoplegi.
• PMID: 23095653 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Gangliosides
• Immunoglobulin M
• Immunoglobulins, Intravenous

Topics

• Aged
• Anemia, Hemolytic, Autoimmune (diagnosis, drug therapy, immunology)
• Ataxia (diagnosis, drug therapy, immunology)
• Chronic Disease (drug therapy)
• Diplopia (diagnosis, drug therapy)
• Exotropia (pathology)
• Female
• Gangliosides (blood, immunology)
• Humans
• Immunoglobulin M (blood)
• Immunoglobulins, Intravenous (therapeutic use)
• Middle Aged
• Monoclonal Gammopathy of Undetermined Significance (diagnosis, drug therapy, immunology)
• Ophthalmoplegia (diagnosis, drug therapy, immunology)
• Polyneuropathies (diagnosis, drug therapy, immunology)
• Treatment Outcome