Susceptibility to toxoplasmic retinochoroiditis is associated with HLA alleles reported to be implicated with rapid progression to AIDS.

Abstract

BACKGROUND/AIMS:

The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC).

METHODS:

98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and without TCR) were studied.

RESULTS:

The HLA-B35 was significantly increased in TRC group (p=0.0038).

CONCLUSION:

The presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.

• Authors: Ana Lúcia G Demarco, Maria de Lourdes V Rodrigues, José Fernando C Figueiredo, Neifi Hassam S Deghaide, Marcelo Bezerra de Menezes, Luís A Demarco, Ana Paula M Fernandes, Eduardo A Donadi
• Journal: Disease markers (Dis Markers) Vol. 33 Issue 6 Pg. 309-12 ( 2012) ISSN: 1875-8630 [Electronic] United States
• PMID: 23089920 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• HLA-B35 Antigen

Topics

• Acquired Immunodeficiency Syndrome (blood, complications, genetics)
• Adult
• Alleles
• Biomarkers (blood)
• Case-Control Studies
• Chorioretinitis (blood, complications, genetics)
• Disease Progression
• Female
• Genetic Predisposition to Disease
• HLA-B35 Antigen (blood)
• Humans
• Male
• Middle Aged
• Toxoplasmosis, Ocular (blood, complications, genetics)