Hypersensitivity pneumonitis due to isocyanates: lung function, clinical and radiological characteristics.

Abstract

The objective of this present study was to describe the clinical-radiological and lung function characteristics of hypersensitivity pneumonitis due to exposure to isocyanates (HPI). Included for study were all those patients diagnosed with HPI (n = 5) from 1995-2010. In all cases, chest CT and complete lung function studies were done. The diagnosis was made with positive specific bronchial provocation tests (BPT). A predominance of males and pattern variability in the radiological alterations were observed. The BPT was positive due to a decline in FVC or DL(CO) in all cases except in one patient in whom the diagnosis was established with clinical criteria. Positive IgG to isocyanates was confirmed in only one patient. The radiological presentation of HPI may be different from the more common HP in our setting and run their course with less clinical affectation on the BPT.

• Authors: Ane Uranga, Mónica Sánchez-Ortiz, Ferran Morell, Maria-Jesus Cruz, Xavier Muñoz
• Journal: Archivos de bronconeumologia (Arch Bronconeumol) Vol. 49 Issue 4 Pg. 169-72 (Apr 2013) ISSN: 1579-2129 [Electronic] Spain
• PMID: 23083998 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 SEPAR. Published by Elsevier España, S.L. All rights reserved.

Chemical References

• Isocyanates

Topics

• Adult
• Alveolitis, Extrinsic Allergic (chemically induced, diagnosis, diagnostic imaging, physiopathology)
• Case-Control Studies
• Humans
• Isocyanates (adverse effects)
• Lung (physiopathology)
• Male
• Middle Aged
• Occupational Diseases (chemically induced)
• Radiography
• Respiratory Function Tests
• Retrospective Studies