Antiplaque and antigingivitis efficacy of an alcohol-free essential-oil containing mouthrinse: a 2-week clinical trial.

Abstract

PURPOSE:

This randomized, examiner blind, parallel group, controlled clinical study evaluated the antiplaque and antigingivitis potential of an alcohol-free essential oils containing mouthrinse (Listerine Zero) compared to a 5% hydroalcohol mouthrinse (negative control), using a 2-week experimental gingivitis model.

METHODS:

92 subjects, male and female, ranging in age from 18-68 years, in good general health, were assigned to one of the two treatment groups: Alcohol-free essential oils containing mouthrinse (LZ) or 5% hydroalcohol negative control (C) rinse. The mean Turesky Modification of the Quigley-Hein Plaque Index (PI) and the mean Modified Gingival Index (MGI) at 2 weeks were the primary efficacy endpoints. Following baseline examinations, subjects received a complete dental prophylaxis and began supervised rinsing with their assigned mouthrinse twice daily for 2 weeks, as their sole oral hygiene measure.

RESULTS:

90 subjects completed the trial. At 2 weeks, LZ was more effective (P<0.001) than C in reducing plaque (23.9%) and gingivitis (10.4%).

• Authors: Christine A Charles, Pejmon Amini, John Gallob, Hongyan Shang, James A McGuire, Rafael Costa
• Journal: American journal of dentistry (Am J Dent) Vol. 25 Issue 4 Pg. 195-8 (Aug 2012) ISSN: 0894-8275 [Print] United States
• PMID: 23082381 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Mouthwashes
• Oils, Volatile

Topics

• Adolescent
• Adult
• Aged
• Analysis of Variance
• Dental Plaque (prevention & control)
• Dental Plaque Index
• Female
• Gingivitis (prevention & control)
• Humans
• Male
• Middle Aged
• Mouthwashes (chemistry, therapeutic use)
• Oils, Volatile
• Periodontal Index
• Single-Blind Method
• Young Adult