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Cognition-enhancing and neuroprotective activities of the standardized extract of Betula platyphylla bark and its major diarylheptanoids.

Abstract
Diarylheptanoids have been the center of the intensive research efforts for Alzheimer's disease and other neurodegenerative diseases. The present study aimed to determine the effect of the standardized extract of B. platyphylla bark and its major diarylheptanoids in scopolamine-induced amnesic mice through cyclic AMP response element-binding protein (CREB) activation. Oral administration of the standardized extract of B. platyphylla bark (100mg/kg body weight), aceroside VIII (1mg/kg body weight) and platyphylloside (1 or 2mg/kg body weight) significantly ameliorated scopolamine-induced amnesia in passive avoidance test. CREB phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the cortex and hippocampus of the scopolamine-treated mice were markedly increased by the treatment of the standardized extract of B. platyphylla bark and platyphylloside. The standardized extract of B. platyphylla bark and its major diarylheptanoids also significantly protected HT22 cells against neurotoxicity induced by glutamate insult. The standardized extract of B. platyphylla bark and platyphylloside may ameliorate memory deficits by activating the CREB-BDNF pathway and prevent a neurodegeneration by inhibiting neuronal cell death.
AuthorsKi Yong Lee, Eun Ju Jeong, Jungmoo Huh, Namki Cho, Tae Bum Kim, Byung Ju Jeon, Seung Hyun Kim, Hong Pyo Kim, Sang Hyun Sung
JournalPhytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine) Vol. 19 Issue 14 Pg. 1315-20 (Nov 15 2012) ISSN: 1618-095X [Electronic] Germany
PMID23079232 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier GmbH. All rights reserved.
Chemical References
  • Brain-Derived Neurotrophic Factor
  • Cyclic AMP Response Element-Binding Protein
  • Diarylheptanoids
  • Neuroprotective Agents
  • Plant Extracts
  • Glutamic Acid
  • Scopolamine
Topics
  • Administration, Oral
  • Amnesia (chemically induced, metabolism, prevention & control)
  • Animals
  • Avoidance Learning (drug effects)
  • Betula (chemistry)
  • Brain (drug effects, metabolism)
  • Brain-Derived Neurotrophic Factor (metabolism)
  • Cell Death (drug effects)
  • Cognition (drug effects)
  • Cyclic AMP Response Element-Binding Protein (metabolism)
  • Diarylheptanoids (pharmacology, therapeutic use)
  • Glutamic Acid
  • Male
  • Mice
  • Mice, Inbred ICR
  • Neurodegenerative Diseases (metabolism, prevention & control)
  • Neuroprotective Agents (pharmacology, therapeutic use)
  • Phytotherapy
  • Plant Bark
  • Plant Extracts (pharmacology, therapeutic use)
  • Reference Standards
  • Scopolamine
  • Signal Transduction

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