Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: The gel from the leaves of Bulbine natalensis (BN) and Bulbine frutescens (BF) is commonly used as a traditional medicine in South Africa for the treatment of skin wounds and burns. Treatment with both leaf gel extracts has previously been demonstrated to increase tensile strength and protein and DNA content in pig dermal wounds. This study examined the effect of the leaf gel extracts in vivo on histology of wound healing in pigs to elucidate the mechanism of increased tensile strength. MATERIALS AND METHODS: RESULTS: Histological analysis of the wound tissue in the study indicated earlier wound contraction and collagen deposition in both treatment groups with re-organisation of the collagen (indicating collagen maturation) evident as early as at day 10. CONCLUSION: The results of this study suggests that the leaf extracts increase tensile strength by increasing fibroplasia, differentiation of fibroblasts into myofibroblasts, and increased collagen deposition and maturation. This study further validates the use of the Bulbine leaf gels for the treatment of skin wounds.
|
Authors | Nalini Pather, Beverley Kramer |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 144
Issue 3
Pg. 523-32
(Dec 18 2012)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 23078885
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Actins
- Gels
- Plant Extracts
- Receptors, Transforming Growth Factor beta
- Vascular Endothelial Growth Factor A
- Collagen
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type I
- Receptor, Transforming Growth Factor-beta Type II
|
Topics |
- Actins
(metabolism)
- Animals
- Collagen
(metabolism)
- Female
- Gels
- Liliaceae
- Medicine, African Traditional
- Phytotherapy
- Plant Extracts
(pharmacology, therapeutic use)
- Plant Leaves
- Protein Serine-Threonine Kinases
(metabolism)
- Receptor, Transforming Growth Factor-beta Type I
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta
(metabolism)
- Skin
(injuries, metabolism, pathology)
- South Africa
- Swine
- Tensile Strength
- Vascular Endothelial Growth Factor A
(metabolism)
- Wound Healing
(drug effects, physiology)
|