The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization.

Abstract

We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (-2578, -1154, -634, and 936) and KDR (-604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF -2578, -1154, -634, and 936 or KDR -604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the -634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF -634 had better collateral vessel formation after surgery. Our results suggest that the VEGF -634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation.

• Authors: Young Seok Park, Young Joo Jeon, Hyun Seok Kim, Kyu Young Chae, Seung-Hun Oh, In Bo Han, Hyun Sook Kim, Won-Chan Kim, Ok-Joon Kim, Tae Gon Kim, Joong-Uhn Choi, Dong-Seok Kim, Nam Keun Kim
• Journal: PloS one (PLoS One) Vol. 7 Issue 10 Pg. e47158 ( 2012) ISSN: 1932-6203 [Electronic] United States
• PMID: 23077562 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factor Receptor-2

Topics

• Adolescent
• Adult
• Asian People (genetics)
• Carotid Arteries (metabolism, physiopathology)
• Case-Control Studies
• Child
• Child, Preschool
• Female
• Haplotypes
• Humans
• Male
• Moyamoya Disease (genetics, physiopathology)
• Neovascularization, Physiologic
• Polymorphism, Single Nucleotide
• Vascular Endothelial Growth Factor A (genetics)
• Vascular Endothelial Growth Factor Receptor-2 (genetics)
• Young Adult