β-
arrestins, including β-arrestin1 and β-arrestin2, are ubiquitous cytosolic
proteins which localize in the cytoplasm and plasma membrane, initially be regarded as an potential character in
G protein-coupled receptors (GPCR) desensitization, sequestration, and internalization. Besides, recent many studies increasingly revealed that β-
arrestins served widely as versatile adapter
proteins for scaffolding many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors and downstream
kinases. As we known, the
biologic and clinical behaviors of many
tumors are largely determined by multiple molecular signal pathways. More recently, accumulating evidences established that β-
arrestins got widely involved in many
cancer developmental signaling events which responsible for
tumor viability and
metastasis, suggesting an impressive role of β-
arrestins in
tumor progression. Because of the regulation and
biological output of β-
arrestins is so complex, the role of β-
arrestins in
cancer development still remains enigmatic. However, the further understanding with the clinical prognosis and oncogenic potential of β-
arrestins might facilitate the identification of diagnosis
biomarkers and development of
drug targets in
cancer. In this article, we reviewed a comprehensive summary of the β-
arrestins-mediated functions in human
cancers.