A comparative study of the effects of daily minodronate and weekly alendronate on upper gastrointestinal symptoms, bone resorption, and back pain in postmenopausal osteoporosis patients.

The purpose of the present study was to precisely compare both the efficacy and abdominal symptom-related quality of life after treatment with daily minodronate and weekly alendronate in patients with primary postmenopausal osteoporosis. The efficacy of the two drugs was assessed based on improvements in a bone turnover marker, back pain, and gastrointestinal symptoms that impair quality of life, which was assessed using the Izumo scale questionnaire. In the minodronate group, there were no significant changes during the treatment period in the specific scores for heartburn, epigastralgia and epigastric fullness, whereas all of the scores were significantly elevated at some time point after drug administration in the alendronate group. Urinary N-telopeptide of type I collagen (uNTX), a bone resorption marker, and bone-specific alkaline phosphatase, a bone formation marker, significantly decreased in both groups, but decreases in uNTX in the minodronate group was observed significantly earlier compared with those in the alendronate group. The back pain scores, which were obtained using a visual analog scale, were significantly reduced in both groups. However, analgesic effects were detected earlier in the minodronate group. In conclusion, compared with weekly alendronate, daily minodronate improved bone turnover and back pain more promptly without causing upper gastrointestinal symptoms.
AuthorsToru Yoshioka, Nobukazu Okimoto, Ken Okamoto, Akinori Sakai
JournalJournal of bone and mineral metabolism (J Bone Miner Metab) Vol. 31 Issue 2 Pg. 153-60 (Mar 2013) ISSN: 1435-5604 [Electronic] Japan
PMID23076293 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Biomarkers
  • Bone Density Conservation Agents
  • Collagen Type I
  • Diphosphonates
  • Imidazoles
  • Peptides
  • collagen type I trimeric cross-linked peptide
  • YM 529
  • Alendronate
  • Aged
  • Alendronate (administration & dosage, adverse effects, therapeutic use)
  • Back Pain (complications, drug therapy, physiopathology, urine)
  • Biomarkers (metabolism)
  • Bone Density (drug effects)
  • Bone Density Conservation Agents (administration & dosage, adverse effects, therapeutic use)
  • Bone Remodeling (drug effects)
  • Bone Resorption (complications, drug therapy, physiopathology, urine)
  • Collagen Type I (urine)
  • Diphosphonates (administration & dosage, adverse effects, therapeutic use)
  • Drug Administration Schedule
  • Female
  • Gastrointestinal Tract (drug effects, pathology)
  • Humans
  • Imidazoles (administration & dosage, adverse effects, therapeutic use)
  • Osteoporosis, Postmenopausal (complications, drug therapy, physiopathology, urine)
  • Pain Measurement
  • Peptides (urine)
  • Surveys and Questionnaires

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: