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Primary sclerosing cholangitis: new approaches to diagnosis, surveillance and treatment.

Abstract
Primary sclerosing cholangitis (PSC) is a chronic inflammatory bile duct disease of unknown etiology, frequently associated with inflammatory bowel disease and leading to end-stage liver disease requiring liver transplantation. Moreover, PSC is a premalignant condition associated with an increased risk for hepatobiliary and colorectal malignancy. Since effective medical therapy for PSC is still lacking, this disorder represents a potentially fatal disease with poor prognosis. This article is a summary of an overview given at the 5th Falk Gastro Conference in Munich 2012 and reviews the challenges associated with diagnosis, surveillance and therapy of PSC.
AuthorsMichael Trauner, Emina Halilbasic, Anna Baghdasaryan, Tarek Moustafa, Elisabeth Krones, Peter Fickert, Harald Hofer, Edward Penner
JournalDigestive diseases (Basel, Switzerland) (Dig Dis) Vol. 30 Suppl 1 Pg. 39-47 ( 2012) ISSN: 1421-9875 [Electronic] Switzerland
PMID23075867 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2012 S. Karger AG, Basel.
Chemical References
  • Ursodeoxycholic Acid
Topics
  • Cholangitis, Sclerosing (diagnosis, drug therapy, epidemiology, therapy)
  • Humans
  • Population Surveillance
  • Ursodeoxycholic Acid (therapeutic use)

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