Inhibition of interleukin 1 (IL-1)-elicited leukocytosis and LPS-induced fever by soluble immune response suppressor (SIRS).

Abstract

IL-1-induced leukocytosis was inhibited or blocked in a dose-dependent manner by SIRS, an antigen-nonspecific suppressive lymphokine, when administered intravenously or per os to CBA mice. Timing experiments showed that SIRS effectively inhibited the leukocytosis when administered within 30 minutes of the IL-1. An antipyrogenic activity of SIRS was observed in rabbits injected intravenously with LPS. SIRS, given intravenously in one or two doses, markedly reduced LPS-induced fever. SIRS (2000 units) was a more effective antipyretic agent than aspirin (3 mg/kg body weight, intramuscularly). The results suggest that SIRS may be a potential drug for use in IL-1-mediated disorders.

• Authors: M Zimecki, H W Schnaper, Z Wieczorek, D R Webb, C W Pierce
• Journal: Immunopharmacology (Immunopharmacology) 1990 Jan-Feb Vol. 19 Issue 1 Pg. 39-46 ISSN: 0162-3109 [Print] Netherlands
• PMID: 2307580 (Publication Type: Journal Article)

Chemical References

• Interleukin-1
• Polysaccharides, Bacterial
• Suppressor Factors, Immunologic
• soluble immune response suppressor

Topics

• Animals
• Bone Marrow (drug effects)
• Bone Marrow Cells
• Female
• Fever (chemically induced, physiopathology)
• Interleukin-1 (antagonists & inhibitors, pharmacology)
• Leukocyte Count
• Leukocytosis (chemically induced)
• Mice
• Mice, Inbred CBA
• Neutrophils (drug effects)
• Polysaccharides, Bacterial (antagonists & inhibitors)
• Rabbits
• Suppressor Factors, Immunologic (pharmacology)