Diagnostic and prognostic value of low density lipoprotein-containing circulating immune complexes in atherosclerosis.

Abstract

Recently, it has been shown that increased level of LDL-containing circulating immune complexes (LDL-CIC) possess high diagnostic significance in clinically manifested atherosclerosis, but little is known about its diagnostic and prognostic significance in early atherosclerosis. Two-years prospective study was performed in 98 asymptomatic men aged 40-74. The rate of atherosclerosis progression was estimated by high-resolution B-mode ultrasonography as the increase in intima-media thickness (IMT) of common carotid arteries. The patients with elevated baseline levels of LDL-CIC were characterized by significantly higher levels of total and LDL cholesterol as well as significantly increased mean IMT of common carotid arteries. Among all baseline lipid parameters, only LDL-CIC and LDL cholesterol were contingent with the extent of early carotid atherosclerosis (p = 0.042 and p = 0.049, respectively) and had the highest levels of relative risk and odds ratio. During the follow up, significant IMT increase was registered in 53.1 % (n = 52) patients, IMT significant reduction was observed in 21.4 % (n = 21) patients. The increased levels of LDL-CIC, total serum cholesterol and LDL cholesterol had similar prognostic significance with the respect of atherosclerosis progression. The normal level of LDL-CIC (below than 16.0 μg/ml) was the only lipid parameter that predicted the absence of carotid atherosclerosis progression for two following years at prognostic value of 78.3 %. The results of the study allow assuming that LDL-CIC level may be employed not only as a marker of early atherosclerosis, but also has a sufficient prognostic value for clinical implications.

• Authors: Igor A Sobenin, Vasily P Karagodin, Alexandra Capital A Cyrillic Melnichenko, Yuri V Bobryshev, Alexander N Orekhov
• Journal: Journal of clinical immunology (J Clin Immunol) Vol. 33 Issue 2 Pg. 489-95 (Feb 2013) ISSN: 1573-2592 [Electronic] Netherlands
• PMID: 23073618 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigen-Antibody Complex
• Biomarkers
• Cholesterol, LDL
• Lipoproteins, LDL

Topics

• Antigen-Antibody Complex (blood)
• Atherosclerosis (blood, diagnosis, immunology)
• Biomarkers (blood)
• Carotid Artery, Common (pathology)
• Cholesterol, LDL (blood)
• Disease Progression
• Humans
• Lipoproteins, LDL (blood)
• Middle Aged
• Prognosis