Abstract | BACKGROUND: MATERIALS AND METHODS: In the present study, ocular inserts of AZT are prepared using alginate, carbopol, and hydroxypropyl methylcellulose (HPMC) to solve the said formulation problem of drug and to facilitate ocular bioavailability. Ocular inserts were prepared by film casting method and the prepared films were subjected to investigations for their physical and mechanical properties, swelling behaviors, ex vivo bioadhesion, and in vitro drug release. Ocular irritation of the developed formulation was also checked by hen's egg chorioallantoic membrane test for ocular irritation potential. RESULTS: The physicochemical, bioadhesive, and swelling properties of films were found to vary significantly depending on the type of polymers used and their combinations. The alginate films exhibited greater bioadhesion and showed higher tensile strength and elasticity than the carbopol films. HPMC addition to the films significantly affected the properties of ocular inserts. Carbopol:HPMC (30:70)-based ocular inserts sustained drug release for longest span of 6 h. The release profile of AZT showed that drug release was by both diffusion and swelling. The formulation was found to be practically nonirritant in ocular irritation studies. CONCLUSION: AZT can therefore be developed as an ocular insert delivery system for the treatment of ocular surface infections.
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Authors | Ritu Mehra Gilhotra, Kalpana Nagpal, Dina Nath Mishra |
Journal | International journal of pharmaceutical investigation
(Int J Pharm Investig)
Vol. 1
Issue 1
Pg. 22-8
(Jan 2011)
ISSN: 2230-9713 [Electronic] India |
PMID | 23071916
(Publication Type: Journal Article)
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