In studies conducted over the last 10 years, the
ATP,
ADP,
AMP concentrations, the adenylate pool (
ATP +
ADP +
AMP), the "energy charge" and the cAMP levels were determined:(1) in gastric tissues of pylorus-ligated rats, (2) in gastric and duodenal mucosa and muscular layer (musculature) of human subjects qualified as "hypacid", "
normacid" and "hyperacid" on the basis of basal (BAO) and maximal
acid output (
MAO), (3) in
ulcer-bearing and non-ulcerous
antral, duodenal and jejunal mucosa and muscular layer of patients with
peptic ulcer, including chronic (essential)
antral,
duodenal ulcer and jejunal
ulcer following gastric resection of
Billroth II-type. Close analysis of the results centres on: (1) the biochemical background of gastric hypersecretion and of ulcerogenesis in pylorus-ligated rats;(2) the extra- and intracellular feedback system operating between the gastric membrane
ATPase and
adenylate cyclase systems, under normal and abnormal conditions of the effector organ; (3) questions related to the regulatory mechanisms of functional activity of the effector organ under
drug effect; (4) the energy structure of the mucosa and muscular layer of corpus ventriculi, antrum and duodenum in patients considered "hypacid", "
normacid" and "hyperacid" on the grounds of the BAO and
MAO values; (5) the interrelationships between human gastric H+--K+-dependent
ATPase system of gastric corpus mucosa; (6) pharmacological regulation of the
ATP--ADcer-free mucosa and musculature of patients with
antral, duodenal and jejunal
ulcers.