The interaction between Metadherin (MTDH) and
Staphylococcal nuclease homology domain containing 1 (SND1) is involved in
tumorigenesis and
tumor progression of several human
malignancies. However, its roles in
colon cancer are still unclear. To investigate the clinical value of MTDH and SND1 expression in
colon cancer. Immunohistochemical staining was performed to detect the expression of MTDH and SND1 using human
colon cancer and their corresponding non-cancerous colon tissues from 196 patients' biopsies. Positive expression of MTDH and SND1 were both increased in
colon cancer tissues compared to paired non-cancerous colon tissues. There was a positive correlation between MTDH and SND1 expression in
colon cancer tissues (r = 0.86, p < 0.001). In addition, their positive expression were both significantly associated with nodal status (both p = 0.02), pathological stage (p = 0.006 and 0.008, respectively) and differentiation (both p = 0.03). Moreover, the overall survival in
colon cancer patients with positive expression of MTDH and SND1 were significantly shorter than those without their expression (both p = 0.01). Furthermore, multivariate Cox regression analysis suggested that positive expression of MTDH and SND1 was an independent poor prognostic predictor in
colon cancer. Our data suggest that the increased expression of MTDH and/or SND1 is closely related to
carcinogenesis, progression, and prognosis of
colon cancer. The co-expression of MTDH/SND1 may be a novel distinctive marker to benefit us in prediction of the prognosis in
colon cancer.