Vitamin D in cutaneous carcinogenesis: part II.

The role of vitamin D in health maintenance and disease prevention in fields ranging from bone metabolism to cancer is currently under intensive investigation. A number of epidemiologic studies have suggested that vitamin D may have a protective effect on cancer risk and cancer-associated mortality. With regard to skin cancer, epidemiologic and laboratory studies suggest that vitamin D and its metabolites may have a similar risk reducing effect. Potential mechanisms of action include inhibition of the hedgehog signaling pathway and upregulation of nucleotide excision repair enzymes. The key factor complicating the association between vitamin D and skin cancer is ultraviolet B radiation. The same spectrum of ultraviolet B radiation that catalyzes the production of vitamin D in the skin also causes DNA damage that can lead to epidermal malignancies. Part II of this continuing medical education article will summarize the literature on vitamin D and skin cancer to identify evidence-based optimal serum levels of vitamin D and to recommend ways of achieving those levels while minimizing the risk of skin cancer.
AuthorsJean Y Tang, Teresa Fu, Christopher Lau, Dennis H Oh, Daniel D Bikle, Maryam M Asgari
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 67 Issue 5 Pg. 817.e1-11; quiz 827-8 (Nov 2012) ISSN: 1097-6787 [Electronic] United States
PMID23062904 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)
CopyrightCopyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Chemical References
  • Hedgehog Proteins
  • Receptors, Calcitriol
  • Vitamin D
  • Carcinoma, Basal Cell (physiopathology, prevention & control)
  • Carcinoma, Squamous Cell (physiopathology, prevention & control)
  • DNA Damage (physiology)
  • Hedgehog Proteins (physiology)
  • Humans
  • Keratinocytes (physiology)
  • Receptors, Calcitriol (metabolism)
  • Signal Transduction (drug effects, physiology)
  • Skin Neoplasms (blood, physiopathology, prevention & control)
  • Vitamin D (blood, physiology)

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