Study of gastro-oesophageal reflux disease in patients with mild-to-moderate chronic obstructive pulmonary disease in India.

Abstract

BACKGROUND AND OBJECTIVE:

To study the incidence and pattern of gastro-oesophageal reflux disease (GORD) in patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) using dual-probe 24-h oesophageal pH recording.

METHODS:

This was a prospective study of 50 patients with mild-to-moderate stage COPD based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. A detailed history of illness along with spirometry was done in all patients. In the study group, reflux symptoms were measured using a validated scoring system. All the patients underwent oesophageal manometry and dual-probe 24-h oesophageal pH recording.

RESULTS:

Symptoms of gastro-oesophageal reflux were present in 38 patients. Twenty-four-hour oesophageal pH monitoring revealed pathological reflux in 31 out of 38 symptomatic and 8 out of 12 asymptomatic patients. The overall rate of GORD was 78% in our study. Only distal GORD was observed in 11 (28.9%), and both distal and proximal GORD was observed in 20 (52.6%) out of the 38 symptomatic subjects. In the remaining 12 asymptomatic patients, eight had GORD. Distal GORD was present in six (50%) patients, and two (16.6%) had both distal and proximal GORD in this group. Isolated proximal GORD was not observed in any patient.

CONCLUSIONS:

There is an increased occurrence of GORD in patients with even mild-to-moderate COPD.

• Authors: Nitish L Kamble, Naushad A Khan, Naresh Kumar, Hemanta K Nayak, Mradul K Daga
• Journal: Respirology (Carlton, Vic.) (Respirology) Vol. 18 Issue 3 Pg. 463-7 (Apr 2013) ISSN: 1440-1843 [Electronic] Australia
• PMID: 23062059 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.

Topics

• Esophageal pH Monitoring
• Esophagus (metabolism, physiopathology)
• Female
• Follow-Up Studies
• Gastroesophageal Reflux (complications, diagnosis, epidemiology)
• Humans
• Incidence
• India (epidemiology)
• Male
• Manometry
• Middle Aged
• Pressure
• Prognosis
• Prospective Studies
• Pulmonary Disease, Chronic Obstructive (complications, diagnosis)
• Severity of Illness Index
• Spirometry