Antioxidant evaluation of heterocyclic compounds by cytokinesis-block micronucleus assay.

Abstract

This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.

• Authors: Dejan Godevac, Vele Tesević, Vlatka Vajs, Slobodan Milosavljević, Miroslava Stanković
• Journal: Mini reviews in medicinal chemistry (Mini Rev Med Chem) Vol. 13 Issue 3 Pg. 431-8 (Mar 2013) ISSN: 1875-5607 [Electronic] Netherlands
• PMID: 23061623 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antioxidants
• Heterocyclic Compounds

Topics

• Animals
• Antioxidants (pharmacology)
• Cytokinesis (drug effects)
• Heterocyclic Compounds (pharmacology)
• Humans
• Micronucleus Tests