Azumolene reverses episodes of malignant hyperthermia in susceptible swine.

Abstract

Azumolene is an analogue of dantrolene with much greater water solubility. Ten swine susceptible to malignant hyperthermia (MH) were triggered into MH episodes via the inhalation of halothane, and azumolene was effective in terminating all of the MH episodes. There was an inverse relationship between the dose of azumolene required to terminate the MH episode and the time it took for the pig to manifest the signs of MH. Azumolene was found to be similar in potency to dantrolene.

• Authors: M Dershwitz, F A Sréter
• Journal: Anesthesia and analgesia (Anesth Analg) Vol. 70 Issue 3 Pg. 253-5 (Mar 1990) ISSN: 0003-2999 [Print] United States
• PMID: 2305975 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Imidazoles
• Muscle Relaxants, Central
• Oxazoles
• azumolene
• Halothane

Topics

• Animals
• Halothane (adverse effects)
• Imidazoles (therapeutic use)
• Injections, Intravenous
• Malignant Hyperthermia (drug therapy)
• Muscle Relaxants, Central (therapeutic use)
• Oxazoles (therapeutic use)
• Swine