New alkaloids and cytotoxic principles from Sinomenium acutum.

Abstract

Two new alkaloids, 2-demethyl-oxypalmatine (1) and 5-ethoxycarbonylsinoracutine (2), were isolated from the rhizomes of Sinomenium acutum, along with thirty-four known compounds. Cytotoxicity of the isolated compounds was examined for the MCF-7, H460, HT-29, and CEM human cancer cell lines. Dauriporphine (16), 6-O-demethylmenisporphine (17), bianfugecine (18), menisporphine (19), and 6-O-demethyldauriporphine (20) showed differential effects in their cytotoxic activity on the target cancer cell lines. Significant angiogenesis inhibitions of 16 and 19 were also observed.

• Authors: Jing-Jy Cheng, Tung-Hu Tsai, Lie-Chwen Lin
• Journal: Planta medica (Planta Med) Vol. 78 Issue 17 Pg. 1873-7 (Nov 2012) ISSN: 1439-0221 [Electronic] Germany
• PMID: 23059629 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Alkaloids
• Angiogenesis Inducing Agents
• Antineoplastic Agents, Phytogenic
• Cytotoxins
• Drugs, Chinese Herbal

Topics

• Alkaloids (isolation & purification, pharmacology)
• Angiogenesis Inducing Agents (analysis, chemistry, pharmacology)
• Antineoplastic Agents, Phytogenic (analysis, chemistry, pharmacology)
• Cytotoxins (isolation & purification, pharmacology)
• Drugs, Chinese Herbal (analysis, chemistry, pharmacology)
• HeLa Cells
• Humans
• Molecular Structure
• Neoplasms (drug therapy)
• Rhizome (chemistry)
• Sinomenium (chemistry)