Abstract |
Two new alkaloids, 2-demethyl-oxypalmatine (1) and 5-ethoxycarbonylsinoracutine (2), were isolated from the rhizomes of Sinomenium acutum, along with thirty-four known compounds. Cytotoxicity of the isolated compounds was examined for the MCF-7, H460, HT-29, and CEM human cancer cell lines. Dauriporphine (16), 6-O-demethylmenisporphine (17), bianfugecine (18), menisporphine (19), and 6-O-demethyldauriporphine (20) showed differential effects in their cytotoxic activity on the target cancer cell lines. Significant angiogenesis inhibitions of 16 and 19 were also observed.
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Authors | Jing-Jy Cheng, Tung-Hu Tsai, Lie-Chwen Lin |
Journal | Planta medica
(Planta Med)
Vol. 78
Issue 17
Pg. 1873-7
(Nov 2012)
ISSN: 1439-0221 [Electronic] Germany |
PMID | 23059629
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Georg Thieme Verlag KG Stuttgart · New York. |
Chemical References |
- Alkaloids
- Angiogenesis Inducing Agents
- Antineoplastic Agents, Phytogenic
- Cytotoxins
- Drugs, Chinese Herbal
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Topics |
- Alkaloids
(isolation & purification, pharmacology)
- Angiogenesis Inducing Agents
(analysis, chemistry, pharmacology)
- Antineoplastic Agents, Phytogenic
(analysis, chemistry, pharmacology)
- Cytotoxins
(isolation & purification, pharmacology)
- Drugs, Chinese Herbal
(analysis, chemistry, pharmacology)
- HeLa Cells
- Humans
- Molecular Structure
- Neoplasms
(drug therapy)
- Rhizome
(chemistry)
- Sinomenium
(chemistry)
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