[Intraoperative suppression of spasticity using intrathecal baclofen].

Abstract

Even in patients with complete loss of sensation and paraplegia after cervical spinal trauma, abdominal operations usually require general or spinal anesthesia due to spasms and increased muscle tone. Both anesthetic types have serious drawbacks under these circumstances, e.g. hyperkalemia induced by relaxation or the impossibility of adequate monitoring of the level of spinal blockade. After an onset time of 1-2 h the intrathecal injection of approx. 100 micrograms baclofen, a spinally acting GABAB-agonist, led to complete and long-lasting suppression of surgically induced spasticity. This could be demonstrated by neurological examination (spasticity scores: Ashworth score, spasm score, clonus score) during 5 neurosurgical operations in 3 patients with paraplegia. Except for slight sedation, the patients had no discomfort during operation. Intrathecal baclofen was also effective against autonomic hyperreflexia, i.e. vegetative dysregulation such as bradycardia or hypertension, provoked by catheterization or bladder surgery.

• Authors: H Müller, R Sarges, J Jouaux, W Runte, L Lampante
• Journal: Der Anaesthesist (Anaesthesist) Vol. 39 Issue 1 Pg. 22-5 (Jan 1990) ISSN: 0003-2417 [Print] Germany
• Vernacular Title: Intraoperative Unterdrückung von Spastik mit intrathekalem Baclofen.
• PMID: 2305948 (Publication Type: English Abstract, Journal Article)

Chemical References

• Baclofen

Topics

• Adult
• Aged
• Baclofen (administration & dosage, therapeutic use)
• Humans
• Injections, Spinal
• Intraoperative Period
• Male
• Muscle Spasticity (drug therapy)
• Paraplegia (complications)
• Urologic Diseases (complications, diagnosis, surgery)