Expression of IL-22, IL-22R and IL-23 in the peri-implant soft tissues of patients with peri-implantitis.

The aim of this study was to compare the expression of interleukin (IL)-22, IL-22R and IL-23 in the peri-implant soft tissues between the peri-implantitis patient group (PG) and peri-implant healthy control group (HG).
The tissues were collected from 12 peri-implantitis patients and eight peri-implant healthy controls. Immunohistochemistry (IHC) and real-time quantitative PCR (qPCR) were performed to analyse the gene expression of IL-22, IL-22R and IL-23p19 in peri-implant soft tissues in the PG and the HG group.
The IHC result showed that number of IL-22, IL-22R, and IL-23p19 positive cells increased in PG than in HG (P<0.05). The result of qPCR demonstrated that the expressions of IL-22 messenger RNA (mRNA) and IL-23p19 mRNA were significantly higher in the PG group compared to the HG group (P<0.05). Gene expression of IL-22R mRNA was higher in the PG group; however, there was no statistically significant difference between these two groups (P>0.05).
This study indicates that there is an increased expression level of IL-22 and IL-23 in patients with peri-implantitis, which may induce expression of related pro-inflammatory cytokines and may further have a crucial role in tissue repair and reconstruction in pathogenesis of peri-implantitis.
AuthorsZhenhua Luo, Hui Wang, Zheng Sun, Wei Luo, Yafei Wu
JournalArchives of oral biology (Arch Oral Biol) Vol. 58 Issue 5 Pg. 523-9 (May 2013) ISSN: 1879-1506 [Electronic] England
PMID23058849 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Ltd. All rights reserved.
Chemical References
  • Interleukin-23 Subunit p19
  • Interleukins
  • RNA, Messenger
  • Receptors, Interleukin
  • interleukin-22
  • interleukin-22 receptor
  • Adult
  • Case-Control Studies
  • Female
  • Humans
  • Interleukin-23 Subunit p19 (biosynthesis, genetics)
  • Interleukins (biosynthesis, genetics)
  • Male
  • Middle Aged
  • Mouth Mucosa (metabolism)
  • Peri-Implantitis (genetics, immunology, metabolism)
  • RNA, Messenger (biosynthesis, genetics)
  • Real-Time Polymerase Chain Reaction
  • Receptors, Interleukin (biosynthesis, genetics)
  • Statistics, Nonparametric

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