HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Sarcomatoid (metaplastic) spindle cell carcinoma arising in a phylloid tumor with massive squamous metaplasia - a case report and review of the literature].

AbstractUNLABELLED:
A 76-years-old woman underwent a partial mastectomy and a low-grade malignant homologous phyllodes tumor measuring 45 mm in maximum diameter was diagnosed. Beyond its typical dual composition the tumor displayed extensive intraductal squamous metaplasia. Approximately in one third of the lesion the original mesenchymal component cytologically and structurally changed which ultimately led to seeming stromal overgrowth. The loose storiform background contained isolated larger atypical elements with ample eosinophilic cytoplasm and obvious mitotic activity. This final fibromatosis-like arrangement was completed either by multiple dispersed abrupt squamous morules or just by pearl-like abortive form of squamous differentiation. Conventional in situ or invasive ductal carcinoma was not present. A combined expression of both low and high molecular weight cytoketatins, S100 protein, p63, CD10 and GFAP confirmed the incomplete basal/myoepithelial phenotype and ultimately led to the diagnosis of a spindle cell metaplastic carcinoma arising in a phyllodes tumor - a neoplasm unpublished so far. A review of the literature concerning epithelial malignancies originating from a milieu of phyllodes tumor guides discussion/speculation over the possible histopathogenesis of this vanishingly rare lesion.
KEYWORDS:
breast - phylloid tumor - phyllodes tumor - spindle cell sarcomatoid/metaplastic carcinoma - squamous metaplasia.
AuthorsZ Kinkor, E Sticová, J Sach, J Rychtera, A Skálová
JournalCeskoslovenska patologie (Cesk Patol) Vol. 48 Issue 3 Pg. 156-60 (Jul 2012) ISSN: 1210-7875 [Print] Czech Republic
Vernacular TitleSarkomatoidní (metaplastický) vřetenobuněčný karcinom prsu vznikající ve fyloidním tumoru s rozsáhlou skvamózní metaplázií - kazuistika a přehled literatury.
PMID23057431 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Biomarkers, Tumor
Topics
  • Biomarkers, Tumor
  • Breast Neoplasms
  • Carcinoma
  • Humans
  • Immunohistochemistry
  • Metaplasia

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: