Abstract | BACKGROUND: The hepatitis B virus is a significant pathogen that causes cirrhosis, and hepatocellular cancer as a result of the damage it causes to liver cells. Its infection affects more than 400 million people globally. Although there is an effective vaccine and treatment methods, almost 1, 000, 000 people die every year. OBJECTIVE: METHODS: RESULTS: Serum TG and LDL levels were higher while serum HDL levels were lower in patients with chronic hepatitis B than in controls but the differences did not reach statistical significance. Serum paraoxonase-1 and arylesterase activities, plasma free sulfhydryl groups, and total antioxidant capacity were significantly lower in patients than in controls (p=0.018, p=0.005, p<0.001, p=0.037 respectively), while lipid hydroperoxide, total oxidant status, and oxidative stress index were significantly higher (for all p<0.001). CONCLUSION:
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Authors | H Karsen, I Binici, M Sunnetcioglu, A I Baran, M R Ceylan, S Selek, H Celik |
Journal | African health sciences
(Afr Health Sci)
Vol. 12
Issue 2
Pg. 114-8
(Jun 2012)
ISSN: 1729-0503 [Electronic] Uganda |
PMID | 23056015
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Biomarkers
- Lipid Peroxides
- Lipids
- Oxidants
- Sulfhydryl Compounds
- Carboxylic Ester Hydrolases
- arylesterase
- Aryldialkylphosphatase
- PON1 protein, human
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Topics |
- Adult
- Aged
- Antioxidants
- Aryldialkylphosphatase
(blood, metabolism)
- Atherosclerosis
(blood, etiology, pathology)
- Biomarkers
(blood)
- Body Mass Index
- Carboxylic Ester Hydrolases
(blood, metabolism)
- Case-Control Studies
- Female
- Hepatitis B, Chronic
(blood, complications)
- Humans
- Lipid Peroxides
(blood)
- Lipids
(blood)
- Male
- Middle Aged
- Oxidants
- Oxidation-Reduction
- Oxidative Stress
- Risk Factors
- Sulfhydryl Compounds
(blood)
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