Abstract | BACKGROUND: METHODS: This study was designed to assess the optimal dose of olopatadine to suppress symptoms of chronic urticarial itch in well-controlled patients. After CU patients were treated with 10 mg olopatadine, patients having a visual analog scale (VAS) itch score of less than 20 were randomly allocated into one of three groups: 10 mg/day (n = 35), 5 mg/day ( n = 30), or no medication (n = 32). RESULTS: The suppressive effects of both the 5 mg and 10 mg olopatadine treatments on the VAS itch score were more significant and longer lasting over a period of 4 weeks than the no-medication treatment. Both the 5-mg group and the 10-mg group showed improved urticarial symptoms and maintained their VAS itch score within normal limits compared to the no-medication group. The differences between the 5-mg and 10-mg groups were not significant. CONCLUSION: These results demonstrate that treatment with olopatadine at a dose of 5 mg once daily is effective and safe for the management and prevention of CU symptoms for itch in well-controlled patients.
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Authors | Teruhiko Makino, Yoshiaki Takegami, Mati Ur Rehman, Yoko Yoshihisa, Waka Ishida, Takashi Toyomoto, Tadamichi Shimizu |
Journal | Clinical, cosmetic and investigational dermatology
(Clin Cosmet Investig Dermatol)
Vol. 5
Pg. 141-6
( 2012)
ISSN: 1178-7015 [Electronic] New Zealand |
PMID | 23055763
(Publication Type: Journal Article)
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